![background image](https://www.muhadharaty.com/files/lectures/022/file22053.pdf_d/file22053001.jpg)
1
L6 Orthopedic D. Wahby Ghalib
Bone Tumors II
Giant Cell Tumor
= osteoclastoma
Benign but locally aggressive
Histology
:
abundant
multinucleated giant cells
Age : 20-40 yr
Site : around the knee
o distal radius
Metaphyseal-epiphyseal
XR : soap – bubble appearance
Rx : curettage + tumouricidal
Hi recurrence rate
Malignant potential : 5%
![background image](https://www.muhadharaty.com/files/lectures/022/file22053.pdf_d/file22053002.jpg)
2
Osteosarcoma
Commonest primary malignant bone tumour in child
Highly malignant
Histology : malignant cells
producing osteoid
10% metastasis at presentation
C/F
Age : 10 -25 yr
Pain : constant & more at night
Swelling
Pathologic # : rarely
XR
Metaphyseal lesion
Usually around the knee
Osteolytic & osteoblastic areas
Soft tissue invasion
sun-ray appearance
Periosteal elevation
Codman`s triangle
Rx
CT + surgery
5 yr survival : 60 %
Ewing sarcoma
Highly malignant
Histology : small round cells
25 % metastasis at presentation
![background image](https://www.muhadharaty.com/files/lectures/022/file22053.pdf_d/file22053003.jpg)
3
C/F
Age 10 -25 yr
Pain
Swelling
Generalized illness & fever
Pathologic # rare
XR
Diaphyseal lesion
Tibia & fibula more common
New bone formation
multiple layers
onion – peel appearance
Rx
CT + surgery
5 yr survival : 60 %
Chondrosarcoma
Slowly growing
Primary or secondary to preexisting lesion
C/F
Age 40 -50 yr
XR
Lytic lesion + flecks of calcification
![background image](https://www.muhadharaty.com/files/lectures/022/file22053.pdf_d/file22053004.jpg)
4
Rx
Surgery
Radio- & chemoresistant
5 yr survival 60 %
Mubark A. Wilkins