Thyroid pdf - labs )dr nadia)

Endocrine System 1

Third Year Class

By Dr. Riyadh A. Ali

Department of Pathology

TUCOM

NORMAL THYROID

This is the normal
appearance of the

thyroid

gland on the anterior trachea
of the neck. The thyroid
gland has a right lobe and a
left lobe connected by a
narrow isthmus. The normal
weight of the thyroid is 10 to
30 grams

Normal thyroid

seen microscopically consists of follicles lined by a an

epithelium and filled with colloid. The follicles vary somewhat in size. The
interstitium, which may contain "C" cells, is not prominent.

Hashimoto's Thyroiditis

Low power microscopic view of a thyroid with

Hashimoto's

thyroiditis

. Note the lymphoid follicle at the right center

Hashimoto's thyroiditis

demonstrates the pink Hurthle cells

at the center and right. The lymphoid follicle is at the left.

Nodular Goiter

This diffusely enlarged thyroid gland is somewhat nodular,

thyroid--a nodular goiter

Grave's

Disease

A diffusely enlarged thyroid gland associated with hyperthyroidism is
known as

Grave's disease

. At low power here, note the prominent

infoldings of the hyperplastic epithelium

At high power, the tall columnar thyroid epithelium with

Grave's disease

lines the

hyperplastic infoldings into the colloid. Note the clear vacuoles in the colloid next to the
epithelium where the increased activity of the epithelium to produce increased thyroid
hormone has led to scalloping out of the colloid

Follicular Neoplasm

This is

follicular neoplasm

(a follicular adenoma histologically)

that is surrounded by a thin white capsule.

Normal thyroid follicles appear at the lower right. The

follicular adenoma

is at the center to

upper left. This adenoma is a well- differentiated neoplasm because it closely resemble normal
tissue. The follicles of the adenoma contain colloid, but there is greater variability in size than
normal.

Papillary Carcinoma

. The larger mass is cystic and contains

papillary excresences.

papillary carcinoma

of the thyroid. The fronds of tissue have

thin fibrovascular cores. The fronds have an overal papillary
pattern.

This is

papillary carcinoma

of thyroid. small psammoma body in the center.

The cells of the neoplasm have clear nuclei.